| Registro completo |
| Provedor de dados: |
BJID
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| País: |
Brazil
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| Título: |
Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil
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| Autores: |
Capobiango,Jaqueline Dario
Breganó,Regina Mitsuka
Navarro,Italmar Teodorico
Rezende Neto,Claudio Pereira
Casella,Antônio Marcelo Barbante
Mori,Fabiana Maria Ruiz Lopes
Pagliari,Sthefany
Inoue,Inácio Teruo
Reiche,Edna Maria Vissoci
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| Data: |
2014-08-01
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| Ano: |
2014
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| Palavras-chave: |
Toxoplasma gondii
Congenital toxoplasmosis
Chorioretinitis
Diagnosis
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| Resumo: |
This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500 g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein > 200 mg/dL presented more brain calcifications (p = 0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400364
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| Editor: |
Brazilian Society of Infectious Diseases
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| Relação: |
10.1016/j.bjid.2013.11.009
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Infectious Diseases v.18 n.4 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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